Publications
For a complete and up-to-date list of publications check Pubmed or Google Scholar.
Lab Publications
Select Publications
Lab Publications
- NEW Rapalog resistance is associated with mesenchymal-type changes in Tsc2-null cells. Valianou M, Filippidou N, Johnson DL, Vogel P, Zhang EY, Liu X, Lu Y, Yu JJ, Bissler JJ, Astrinidis A. 2019 Scientific Reports 9:3015. doi: 10.1038/s41598-019-39418-5. PMID: pending Full Text
- NEW Tuberous sclerosis complex exhibits a new renal cystogenic mechanism. Bissler JJ, Zadjali F, Bridges D, Astrinidis A, Barone S, Yao Y, Redd JR, Siroky BJ, Wang Y, Finley JT, Rusiniak ME, Baumann H, Zahedi K, Gross KW, Soleimani M. Physiological Reports. 2019 Jan;7(2):e13983. doi: 10.14814/phy2.13983. PMID: 30675765 Full Text
- Mutational analysis of TSC1 and TSC2 genes in Tuberous Sclerosis Complex patients from Greece. Avgeris S, Fostira F, Vagena A, Ninios Y, Delimitsou A, Vodicka R, Vrtel R, Youroukos S, Stravopodis DJ, Vlassi M, Astrinidis A, Yannoukakos D, Voutsinas GE. Scientific Reports 7:1667. doi: 10.1038/s41598-017-16988-w. PMID: 29196670 Full Text
- The Ribosomal Protein S19 Suppresses Antitumor Immune Responses via the Complement C5a Receptor 1. Markiewski MM, Vadrevu SK, Sharma SK, Chintala NK, Ghouse S, Cho JH, Fairlie DP, Paterson Y, Astrinidis A, Karbowniczek M. J Immunol. 2017 Apr 1;198(7):2989-2999. doi: 10.4049/jimmunol.1602057. Epub 2017 Feb 22. PMID: 28228558 Full Text
- Quantifying autophagosomes and autolysosomes in cells using imaging flow cytometry. Rajan R, Karbowniczek M, Pugsley HR, Sabnani MK, Astrinidis A, La-Beck NM. Cytometry A. 2015 May;87(5):451-8. doi: 10.1002/cyto.a.22652. Epub 2015 Feb 27. PMID: 25728685 Full Text
- Pharmacological inhibition of Polo-like kinase 1 (PLK1) by BI-2536 decreases the viability and survival of hamartin and tuberin deficient cells via induction of apoptosis and attenuation of autophagy. Valianou M, Cox AM, Pichette B, Hartley S, Paladhi UR, Astrinidis A. Cell Cycle. 2015;14(3):399-407. doi: 10.4161/15384101.2014.986394. PMID: 25565629 Full Text
- TACC3-TSC2 maintains nuclear envelope structure and controls cell division. Gómez-Baldó L, Schmidt S, Maxwell CA, Bonifaci N, Gabaldón T, Vidalain PO, Senapedis W, Kletke A, Rosing M, Barnekow A, Rottapel R, Capellá G, Vidal M, Astrinidis A, Piekorz RP, Pujana MA. Cell Cycle. 2010 Mar 15;9(6):1143-55. doi: 10.4161/cc.9.6.11018. PMID: 20237422 Full Text
- The transcription factor SP1 regulates centriole function and chromosomal stability through a functional interaction with the mammalian target of rapamycin/raptor complex. Astrinidis A, Kim J, Kelly CM, Olofsson BA, Torabi B, Sorokina EM, Azizkhan-Clifford J. Genes Chromosomes Cancer. 2010 Mar;49(3):282-97. doi: 10.1002/gcc.20739. PMID: 20013896 Full Text
- The p53 target Plk2 interacts with TSC proteins impacting mTOR signaling, tumor growth and chemosensitivity under hypoxic conditions. Matthew EM, Hart LS, Astrinidis A, Navaraj A, Dolloff NG, Dicker DT, Henske EP, El-Deiry WS. Cell Cycle. 2009 Dec 15;8(24):4168-75. doi: 10.4161/cc.8.24.10800. PMID: 20054236 Full Text
- Estrogen promotes the survival and pulmonary metastasis of tuberin-null cells. Yu JJ, Robb VA, Morrison TA, Ariazi EA, Karbowniczek M, Astrinidis A, Wang C, Hernandez-Cuebas L, Seeholzer LF, Nicolas E, Hensley H, Jordan VC, Walker CL, Henske EP. Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2635-40. doi: 10.1073/pnas.0810790106. Epub 2009 Feb 6. PMID: 19202070 Full Text
Select Publications
- Pharmacological inhibition of Polo-like kinase 1 (PLK1) by BI-2536 decreases the viability and survival of hamartin and tuberin deficient cells via induction of apoptosis and attenuation of autophagy. Valianou M, Cox AM, Pichette B, Hartley S, Paladhi UR, Astrinidis A. Cell Cycle. 2015;14(3):399-407. Full Text
- Hamartin, the tuberous sclerosis complex 1 gene product, interacts with polo-like kinase 1 in a phosphorylation-dependent manner. Astrinidis A, Senapedis W, Henske EP. Hum Mol Genet. 2006 Jan 15;15(2):287-97. Full Text
- Cell cycle-regulated phosphorylation of hamartin, the product of the tuberous sclerosis complex 1 gene, by cyclin-dependent kinase 1/cyclin B. Astrinidis A, Senapedis W, Coleman TR, Henske EP. J Biol Chem. 2003 Dec 19;278(51):51372-9. Full Text
- Tuberin, the tuberous sclerosis complex 2 tumor suppressor gene product, regulates Rho activation, cell adhesion and migration. Astrinidis A, Cash TP, Hunter DS, Walker CL, Chernoff J, Henske EP. Oncogene. 2002 Dec 5;21(55):8470-6. Full Text
- Mutations in the tuberous sclerosis complex gene TSC2 are a cause of sporadic pulmonary lymphangioleiomyomatosis. Carsillo T, Astrinidis A, Henske EP. Proc Natl Acad Sci U S A. 2000 May 23;97(11):6085-90. Full Text
- TACC3-TSC2 maintains nuclear envelope structure and controls cell division. Gómez-Baldó L, Schmidt S, Maxwell CA, Bonifaci N, Gabaldón T, Vidalain PO, Senapedis W, Kletke A, Rosing M, Barnekow A, Rottapel R, Capellá G, Vidal M, Astrinidis A, Piekorz RP, Pujana MA. Cell Cycle. 2010 Mar 15;9(6):1143-55. Full Text
- Estrogen promotes the survival and pulmonary metastasis of tuberin-null cells. Yu JJ, Robb VA, Morrison TA, Ariazi EA, Karbowniczek M, Astrinidis A, Wang C, Hernandez-Cuebas L, Seeholzer LF, Nicolas E, Hensley H, Jordan VC, Walker CL, Henske EP. Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2635-40. Full Text
- Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent. Karbowniczek M, Cash T, Cheung M, Robertson GP, Astrinidis A, Henske EP. J Biol Chem. 2004 Jul 16;279(29):29930-7. Full Text
- Recurrent lymphangiomyomatosis after transplantation: genetic analyses reveal a metastatic mechanism. Karbowniczek M, Astrinidis A, Balsara BR, Testa JR, Lium JH, Colby TV, McCormack FX, Henske EP. Am J Respir Crit Care Med. 2003 Apr 1;167(7):976-82. Full Text
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