TSC and LAM at a glance
Tuberous Sclerosis Complex (TSC)
Sporadic Lymphangioleiomyomatosis (LAM)
- Incidence: 1 in 5,800
- Number of patients: 75-100 thousand in the US, 1.2-1.5 million world-wide
- Organs affected primarily: brain, skin, kidneys, lungs
- Cause: mutations in TSC1 and TSC2, hyperactivation of mTOR
Sporadic Lymphangioleiomyomatosis (LAM)
- Incidence 3-5 per million
- Number of patients: 1,000-1500 in the US, 20-40 thousand worldwide
- Organs affected: lungs, kidneys, lymphatics
- Cause: mutations in TSC2, hyperactivation of mTOR
Updated 5 March 2018