TSC and LAM at a glance

Tuberous Sclerosis Complex (TSC)
  • Incidence: 1 in 5,800
  • Number of patients: 75-100 thousand in the US, 1.2-1.5 million world-wide
  • Organs affected primarily: brain, skin, kidneys, lungs
  • Cause: mutations in TSC1 and TSC2, hyperactivation of mTOR

Sporadic Lymphangioleiomyomatosis (LAM)
  • Incidence 3-5 per million
  • Number of patients: 1,000-1500 in the US, 20-40 thousand worldwide 
  • Organs affected: lungs, kidneys, lymphatics
  • Cause: mutations in TSC2, hyperactivation of mTOR
Updated 5 March 2018
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